Motorola One Power Gets Certified on TENAA; Specifications, Design Revealed

Motorola One Power Gets Certified on TENAA; Specifications, Design Revealed

Motorola One Power or Moto One Power is expected to be the next offering in the Lenovo-owned smartphone brand’s mid-range segment, due for launch at an event on August 2 in Chicago. The Motorola One and Moto Z3 are also expected at this event. After having been leaked and been spotted in various instances in the past, a substantial leak has now surfaced just days before the Motorola One Power’s alleged unveiling. As per the leak, the upcoming Moto-branded smartphone will arrive with a large 4,850mAh battery, a vertical dual rear camera setup, and up to 6GB of RAM.

As is tradition, the Motorola One Power has made its way to certification portal TENAA in China. Colour variants listed in the TENAA database are Black, Gold, Silver, and White. Let’s have a look at what all specifications have been detailed.

Motorola One Power specifications

As per the listing on Chinese certification website TENAA, the Motorola One Power will run Android 8.1 Oreo, and sport a 6.18-inch full-HD+ display with a 1080×2246 pixels resolution and an 18.7:9 aspect ratio. The listing does not show a display notch on the smartphone, however previous renders have pointed towards the presence of one. The phone is powered by an octa-core SoC clocked at 1.8GHz, possibly the Qualcomm Snapdragon 636. This is coupled with 3GB/ 4GB/ 6GB of RAM and 32GB/ 64GB of onboard storage. Storage will be expandable via microSD card (up to 128GB).

In terms of optics, the TENAA listing reveals the presence of a dual camera setup at the back with a 16-megapixel primary sensor and a 5-megapixel secondary sensor. On the front, there might be an 8-megapixel or a 12-megapixel sensor for selfies and video calling. Connectivity options include 4G VoLTE, Bluetooth, and USB. As for sensors, it will come with accelerometer, ambient light sensor, and proximity sensor. As mentioned, there will be a 4,850mAh battery under the hood, with support for Moto’s TurboPower charging. Dimensions mentioned in the listing are 155.8×75.9×9.98mm and weight is 170 grams.

[“Source-gadgets.ndtv”]

Redmi Note 5 Pro, Mi TV 4, and Mi TV 4A Flash Sales in India Today; Redmi 5A to Go Up for Pre-Orders

Redmi Note 5 Pro, Mi TV 4, and Mi TV 4A Flash Sales in India Today; Redmi 5A to Go Up for Pre-Orders

Xiaomi is holding flash sales for the Redmi Note 5 Pro, as well as the Mi TV 4 and Mi TV 4A models, at 12pm IST today. The flash sales will be held on both Mi.com as well as Flipkart. The company will also make the Redmi 5A available for “pre-order” on Mi.com at the same time. The Redmi Note 5 Pro was launched back in February, but still remains popular, with Counterpoint’s Q2 India smartphone shipments report ranking it second on the top-selling smartphone list. The budget Redmi 5A (which was launched in November last year) topped that list, with Xiaomi’s Redmi Note 5 (launched alongside the Redmi Note 5 Pro) taking the fourth spot.

The Redmi Note 5 Pro price in India starts at Rs. 14,999 for the 4GB RAM/ 64GB storage model, and goes up to Rs. 16,999 for the 6GB RAM/ 64GB storage model. It will be available in Black, Blue, Gold, and Rose Gold colour variants. On Mi.com, the company is touting a Rs. 2,200 cashback with up to 4.5TB additional data on Jio, as well as a 3-month subscription to Hungama Music.

The Redmi 5A price in India starts at Rs. 5,999 for the 2GB RAM/ 16GB storage variant, and goes up to Rs. 6,999 for the 3GB RAM/ 32GB storage variant. It will be available in Blue, Dark Grey, Gold, and Rose Gold colour variants. The company is touting a Rs. 2,200 cashback with Jio Rs. 198 and Rs. 299 plans, apart from a 3-month subscription to Hungama Music. To recall, “pre-orders” on Mi.com are said to be a way to skip the queues of flash sales, and book the smartphone with an advance payment (no cash on delivery option) and a delivery time of 5 business days.

As for the televisions, the 55-inch Mi LED Smart TV 4 price in India is set at Rs. 44,999, and it comes with free 3-month subscriptions to Hungama Play and Sony LIV on Mi.com. The 43-inch Mi LED Smart TV 4Aprice in India is Rs. 22,999, and it has the same bundled offers on Mi.com, with a JioFi cashback offer in addition. The 32-inch Mi LED Smart TV 4A price in India is Rs. 13,999, and it has the same offers as the 43-inch model.

[“Source-gadgets.ndtv”]

Huawei Nova 3i, Nova 3 With 4 Cameras, 128GB Storage Launched: Price in India, Specifications

Huawei Nova 3i, Nova 3 With 4 Cameras, 128GB Storage Launched: Price in India, Specifications

The Nova 3i and Nova 3 has been launched in India by Huawei on Thursday. Today, at an event in New Delhi, Huawei unveiled the Nova 3 and Nova 3i for the Indian market and also announced the availability and pricing details of the handsets. The key features of the two smartphones are 6.3-inch full-HD+ displays and dual camera setups on both front and back. Other features of the Huawei Nova 3i include the new HiSilicon Kirin 710 SoC and a 3340mAh battery, while the Nova 3 is powered by a HiSilicon Kirin 970 SoC and a 3750mAh battery. Both the handsets come with 19.5:9 displays and notch-based designs. Notably, Amazon India will be the exclusive online retail partner for Huawei’s new Nova series in India, the company had confirmed earlier. The company also announced the Huawei AI Shopping feature, powered by Amazon, letting users find products by image or camera.

Huawei Nova 3, Nova 3i price in India, launch offers

The Huawei Nova 3 price in India has been set at Rs. 34,999, and it will be available in a 6GB RAM/ 128GB storage variant. Meanwhile, Huawei Nova 3i price in India has been set at Rs. 20,990 for the 4GB RAM/ 128GB inbuilt storage variant. Both the smartphones will be available in the country in Iris Purple and Black colour variants.

 

Huawei Nova 3 and Nova 3i will go up for pre-booking on Amazon India at 2pm IST today itself. Launch offers for both include an additional Rs. 2,000 exchange discount, no-cost EMIs, and Rs. 1,200 cashback from Jio, as well as 100GB additional data. The former will go on sale for the first time on August 23, while the latter will go on sale for the first time on August 7. Pre-booking offers for both phones include a Rs. 1,000 cashback.

Huawei Nova 3 specifications

The dual-SIM (Nano) and dual-VoLTE Huawei Nova 3 runs EMUI 8.2 based on Android 8.1 Oreo and features a 6.3-inch (1080×2340 pixels) full HD+ display with a 19.5:9 aspect ratio and 85 percent NTSC colour gamut. Under the hood, there is an octa-core Huawei HiSilicon Kirin 970 SoC, coupled with Mali-G72 GPU and 6GB of RAM. The dual rear camera setup of the handset includes a 16-megapixel primary sensor with an f/1.8 aperture and PDAF and a 24-megapixel secondary sensor with an f/1.8 aperture. Similar to the back, there is a dual camera setup at the front as well that comprises a 24-megapixel primary sensor with an f/2.0 aperture and a 2-megapixel secondary sensor. The rear camera setup supports AI scene recognition.

huawei nova 3 back gadgets 360 1532590859236 Huawei Nova 3i Price in India Launch

Huawei Nova 3, seen from the back

 

The Huawei Nova 3 has 128GB of inbuilt storage that is expandable via microSD card (up to 256GB). The smartphone has 4G VoLTE, Wi-Fi 802.11ac, Bluetooth v4.2, GPS/ A-GPS, USB Type-C, and a 3.5mm headphone jack for connectivity. It also includes a fingerprint sensor at the back and supports a Face Unlock feature as well. Besides, the smartphone packs a 3750mAh battery and measures 157×73.7×7.3mm.

Huawei Nova 3i specifications
The dual-SIM (Nano) and dual-VoLTE Huawei Nova 3i runs EMUI 8.2 based on top of Android 8.1 Oreo out-of-the-box. It sports a 6.3-inch full-HD+ (1080×2340 pixels) LTPS panel with a 19.5:9 aspect ratio and pixel density of 409ppi. The handset is powered by an in-house octa-core HiSilicon Kirin 710 SoC, paired with 4GB of RAM.

In the camera department, the Huawei Nova 3i bears a vertically stacked dual rear camera setup with a 16-megapixel primary sensor and a 2-megapixel secondary sensor. Even the front of the handset has a dual camera setup with a 24-megapixel primary sensor and a 2-megapixel secondary unit. The smartphone is equipped with 128GB of inbuilt storage, expandable via microSD card (up to 256GB).

huawei nova 3i front back gadgets 360 Huawei Nova 3i Price in India Launch

Huawei Nova 3i, seen from front and back

 

Connectivity options in the Huawei Nova 3i include 4G LTE, dual-band Wi-Fi 802.11ac, Bluetooth v4.2 LE, USB 2.0, GLONASS, and GPS/ A-GPS. Sensors onboard the Huawei Nova 3i include an accelerometer, ambient light sensor, digital compass, gyroscope, and proximity sensor. There is a 3340mAh battery behind the hood. The Nova 3i measures 157.6×75.2×7.6mm and weighs about 169 grams.

[“Source-gadgets.ndtv”]

Don’t ignore dizziness when standing up, you may be at risk of dementia

  • Dizziness,health,Wellness
  • People who feel faint, dizzy or lightheaded when standing up, caused by a sudden drop in blood pressure, may be at greater risk of developing dementia or stroke decades later, according to a study done by Johns Hopkins Bloomberg School of Public Health in the US.
  • The study, published in journal of the American Academy of Neurology, involved 11,709 people with an average age of 54, who were followed for 25 years. None had a history of heart disease or stroke at the beginning of the study.
  • “Orthostatic hypotension has been linked to heart disease, fainting and falls, so we wanted to conduct a large study to determine if this form of low blood pressure was also linked to problems in the brain, specifically dementia,” said Andreea Rawlings, from Johns Hopkins Bloomberg School of Public Health.
  • For the study, low blood pressure upon standing was defined as a drop of at least 20 millimetres of mercury (mmHg) in systolic blood pressure, which is the pressure in the blood vessels when the heart beats, or at least 10 mmHg in diastolic blood pressure, the pressure when the heart is at rest. Normal blood pressure is less than 120/80 mmHg. During the initial exam, participants were screened for orthostatic hypotension. They were instructed to lie down for 20 minutes and then stand up in a smooth, swift motion.
  • Researchers found those who had orthostatic hypotension at the beginning of the study had a 54% higher risk of developing dementia than those who did not have orthostatic hypotension at the beginning of the study.
  • “Measuring orthostatic hypotension in middle-age may be a new way to identify people who need to be carefully monitored for dementia or stroke,” said Rawlings. “More studies are needed to clarify what may be causing these links as well as to investigate possible prevention strategies,” she said.
  • [“source=hindustantimes”]

Why multiple pregnancies can make your cells age faster

Pregnancy,Health,Wellness

Multiple pregnancy makes women’s cells age more quickly, according to a study that may explains why women with many children tend to show signs of accelerated ageing. The findings, published in the journal Scientific Reports, were reached by looking at two separate markers of cellular ageing — telomere length and epigenetic age — in hundreds of young women with different reproductive histories in the Philippines.

“Telomere length and epigenetic age are cellular markers that independently predict mortality, and both appeared ‘older’ in women who had more pregnancies in their reproductive histories,” said Calen Ryan, a doctoral student at University of Washington in the US. “Even after accounting for other factors that affect cellular ageing, the number of pregnancies still came out on top,” said Ryan.

Cellular ageing was accelerated by between 0.5 and 2 years for each additional pregnancy, a surprisingly large effect according to the researchers. Another finding they did not expect was the fact that women who were currently pregnant had cells that looked younger — not older — than predicted.

“Paradoxically, even though a woman’s biological age was higher with each child that she had, if a woman was pregnant when the measurements were taken, her epigenetic age, and to a lesser extent her telomeres, looked ‘younger’ than predicted for her chronological age,” said Christopher Kuzawa of Northwestern University in the US.

“It’s an interesting situation in which pregnancy makes someone look temporarily ‘young’, but there appears to be some lasting, cumulative relationship between the number of pregnancies and more accelerated biological age,” said Kuzawa.

Researchers have known from historical records and epidemiological studies that women who have many children tend to have slightly shorter lives and succumb to different diseases than those who do not. “What we didn’t know was whether we could detect these kind of effects using measures of cellular ageing,” Ryan said.

Although there is good evidence that having more children, especially more than four or five, can increase the risk of certain diseases and shorten lifespan, researchers still do not really know why. “Our study points to cellular changes during pregnancy, possibly related to adaptive changes in the mother’s immune system as a possible explanation,” said Kuzawa.

“There’s still a lot we don’t know. For instance, it’s not clear whether these relationships will persist into later life as these women age. We also do not know whether these changes will actually lead to less favourable long-term health outcomes,” he said.

To answer these questions, a follow-up study on the same women 13 years after the first measurements, taken in 2005, is already underway.

[“source=hindustantimes”]

Don’t take insomnia lightly, here are 5 health conditions caused by sleep disorders

Insomnia,Health,Wellness

While all of us have, at some point, had some trouble sleeping, insomnia is not to be taken lightly. In fact, it is linked to several diseases as well, be it Type 2 diabetesweight lossproblems, heart disease, and pregnancy complications. There are several factors that can cause insomnia, be it stress, eating the wrong diet, excess exercise or a mental disorder. And just by having sound sleep, you can reduce your risk of chronic illness, keep your brain and digestion healthy, and boost your immune system as well.

Some of the best ways to get good sleep is to avoid eating or drinking just before bed, making the sleep environment comfortable, decreasing caffeine and alcohol intake, thinking happy thoughts and sticking to a sleep schedule.

Here are 5 effects of insomnia on your health:

Research shows a genetic link between insomnia and psychiatric diseases like depression. (Shutterstock)

A 2018 study shows a genetic link between insomnia and psychiatric disorders and metabolic diseases such as type 2 diabetes. The researchers also identified specific genes that cause sleep problems and concluded that depression is “partially heritable”. The study was published in the journal Molecular Psychiatry this week.

Sleep deprivation can causes βeta-cell dysfunction and increase inflammation and oxidative stress, which leads to worsening glycaemic control in people with diabetes, according to the International Textbook of Diabetes Mellitus.

Insomnia was also linked with a higher risk of developing heart disease over 10 years among 86,329 postmenopausal women, according to the US National Institutes of Health Women’s Health Initiative.

Insomnia can hamper your weight loss plans by affecting digestion, detoxification and hunger mechanism. (Shutterstock)

Insomnia can also make it tougher to lose weight. as one of the health benefits of sleep is detoxification. When you sleep, your organs undergo detoxification. Sleep also improves digestion, and helps you maintain equilibrium in the body, and a healthy body weight. The hormones that are responsible for making you fall asleep are the same ones that control appetite. So, a sleep disorder can lead to greater appetite and eventually weight gain.

Insomnia can also impact women during pregnancy and is a risk factor for high blood pressure and pre-eclampsia, gestational diabetes, depression, premature birth and unplanned caesarean sections.

[“source=hindustantimes”]

Infants Should Be Breastfed In The First Hour Of Birth: Benefits

Infants Should Be Breastfed In The First Hour Of Birth: Benefits

According to United Nations Children’s Fund (UNICEF) and World Health Organization (WHO), around 78 million babies or three in every five are not breastfed within the first hour of the birth, putting them at a higher risk of death and disease and making them less likely to continue breastfeeding. Most of these babies are born in low- and middle-income countries. According to the report, newborns who breastfeed in the first hour of life are significantly more likely to survive. Even a delay of a few hours after birth could pose life-threatening consequences.

It should be noted that skin-to-skin contact along with suckling at the breast stimulates the mother’s production of breast milk, including colostrum, also called the baby’s ‘first vaccine’, which is extremely rich in nutrients and antibodies.

UNICEF Executive Director Henrietta H. Fore said, “When it comes to the start of breastfeeding, timing is everything. In many countries, it can even be a matter of life or death,” adding, “Yet each year, millions of newborns miss out on the benefits of early breastfeeding and the reasons – all too often – are things we can change. Mothers simply don’t receive enough support to breastfeed within those crucial minutes after birth, even from medical personnel at health facilities.”

Breastfeeding rates within the first hour after birth are highest in Eastern and Southern Africa (65%) and lowest in East Asia and the Pacific (32%), the report says.

Nearly nine in 10 babies born in Burundi, Sri Lanka and Vanuatu are breastfed within the first hour.

WHO Director-General Dr Tedros Adhanom Ghebreyesus said, “Breastfeeding gives children the best possible start in life,” adding, “We must urgently scale up support to mothers – be it from family members, health care workers, employers and governments, so they can give their children the start they deserve.”

Capture the Moment, which analyzed data from 76 countries, found that despite the importance of early initiation of breastfeeding, too many newborns are left waiting too long for different reasons, including:

Feeding newborns food or drinks, including formula: Common practices, such as discarding colostrum, an elder feeding the baby honey or health professionals giving the newborn a specific liquid, such as sugar water or infant formula, delay a newborn’s first critical contact with his or her mother.

The rise in elective C-sections: In Egypt, caesarean section rates more than doubled between 2005 and 2014, increasing from 20% to 52%. During the same period, rates of early initiation of breastfeeding decreased from 40% to 27%. A study across 51 countries notes that early initiation rates are significantly lower among newborns delivered by caesarean section. In Egypt, only 19% of babies born by C-section were breastfed in the first hour after birth, compared to 39% of babies born by natural delivery.

Gaps in the quality of care provided to mothers and newborns: The presence of a skilled birth attendant does not seem to affect rates of early breastfeeding, according to the report. Across 58 countries between 2005 and 2017, deliveries at health institutions grew by 18 percentage points, while early initiation rates increased by 6percentage points. In many cases, babies are separated from their mothers immediately after birth and guidance from health workers is limited.

Earlier studies, cited in the report, show that newborns that began breastfeeding between two and 23 hours after birth had a 33% greater risk of dying compared with those who began breastfeeding within one hour of birth.

Among newborns that started breastfeeding a day or more after birth, the risk was more than twice as high.

The report urges governments, donors and other decision-makers to adopt strong legal measures to restrict the marketing of infant formula and other breastmilk substitutes.

The WHO and UNICEF-led Global Breastfeeding Collective, which tracks progress for breastfeeding policies and programmes also released the 2018 Global Breastfeeding Scorecard.

In it, they encourage countries to advance policies and programmes that help all mothers to start breastfeeding in the first hour of their child’s life and to continue as long as they want.

[“source=doctor.ndtv”]a

Chronotherapy Could Make Cancer Treatments More Effective, Here’s How

Chronotherapy Could Make Cancer Treatments More Effective, Here

Chi Van Dang generally declines to discuss the science that made him famous. A leading authority on cancer metabolism, he routinely is asked to speak about how tumors reprogram biochemical pathways to help them slurp up nutrients and how disrupting these noxious adaptations could be a powerful approach to treating cancer. Instead of doing so, Dang uses his soapbox at every research meeting, lecture and blue-ribbon panel to advocate for something else: a simple yet radical tweak to how oncologists administer cancer drugs.

The approach, known as chronotherapy, involves timing delivery of drugs to minimize side effects while maximizing effectiveness. The idea is to synchronize therapy with the body’s natural 24-hour rhythms — the circadian clock — and striking when cancer cells are most vulnerable or when healthy cells are least sensitive to toxicity (or, ideally, both).

Dang didn’t set out to become an ambassador for this field. But as scientific director of the Ludwig Institute for Cancer Research, a nonprofit that funds cancer labs worldwide, and chair of the board of scientific advisers at the National Cancer Institute, he finds himself in a powerful position to reshape the research agenda — and he believes chronotherapy’s time has come.

It is not an entirely new concept. Some trials in the 1980s and 1990s showed dramatic reductions in toxicities and extended survival times among cancer patients who were treated in a clock-optimized fashion. But mostly “it’s just always been on the fringe,” says Dang. “There weren’t that many card-carrying cancer biologists like me getting into it.”

Until now.

Researchers are finding new ways to administer old drugs and they are devising clever tactics for rewiring aberrant clocks. They are transforming a strategy long dismissed as complementary or alternative medicine into rigorous science. Last year, the NCI — the largest funder of cancer research in the world — put out a call for grant applications from scientists seeking to understand how circadian processes affect tumor development and the responses of patients to therapy.

“It’s capturing people’s interest,” Dang says.

A slender and bespectacled 63-year-old with the confident and unhurried voice of a seasoned physician, Dang cites his father — Chieu Van Dang, Vietnam’s first neurosurgeon and a former dean of the University of Saigon School of Medicine — as a role model. His father’s death from liver cancer in 2004 remains an inspiration to develop better treatments.

Family also was a driving factor behind a career move that prompted Dang’s embrace of circadian biology. He had spent nearly 25 years at Johns Hopkins University, rising to vice dean for research of the medical school; he figured he’d never leave. But in 2011, after his older brother Bob died of cancer, Dang said he thought, “I need to do more.”

So when the University of Pennsylvania approached him that year with an offer to become director of its cancer center, he jumped.

Penn also is home to one of the nation’s largest groups of chronobiology researchers, and Dang found himself chatting and collaborating with clock researchers across the campus. It prompted an epiphany: If cancer is a disease of runaway cell growth and if circadian rhythms keep cell cycles in check, then disrupting the internal clock must be, as Dang puts it, a “missing link” of tumor development and growth.

The circadian clock is a complex biological circuit that controls daily rhythms of sleep, eating, body temperature and more. There is a master clock that sits in the brain, secondary clocks in other organs and clocks in each cell, controlled by a network of genes and proteins that oscillate their activity levels in periodic cycles.

When these clocks are in sync, the body operates properly. But when clock genes are mutated or thrown off by jet lag, these systems can get out of whack, which can create conditions for tumors to grow and spread.

Early hints that disrupted clocks could lead to cancer came in 2001, when two teams of epidemiologists concluded that women who regularly worked night shifts had increased chances of developing breast cancer. Later studies established links between graveyard shifts and cancers of the colon, prostate and endometrium — which prompted the World Health Organization’s International Agency for Research on Cancer in 2007 to designate night-shift work involving circadian disruption as a probable carcinogen.

Researchers now generally believe that nocturnal light, which decreases the body’s natural production of the clock-regulating hormone melatonin, explains such a link. This suggests that melatonin pills or modulating ambient lighting could help mitigate risk among shift workers.

But, says Steven Hill, a circadian cancer researcher at Tulane University, “there are no published studies or active interventional studies” to back that up.

In part, that’s because prevention trials of this kind would be hugely expensive and lengthy — and also because many researchers are instead focused on treatment strategies for people who already have a cancer diagnosis. Earlier this year, for example, a team at the Salk Institute for Biological Studies in La Jolla, California, described two novel drugs that target key clock components and kill several types of cancer cells in a laboratory dish while also slowing the growth of brain tumors in mice.

By reawakening circadian clocks in cancer cells, the drugs seemed to block biological functions that tumors rely upon.

Dang’s own research has focused mainly on showing how a notorious cancer gene named MYC suppresses genes at the core of the mammalian clock. This suppression pushes cells into aberrant, perpetual activity that drives tumor progression. Last year, researchers at Texas Children’s Cancer Center reported that a drug that indirectly stimulates one of these clock genes, BMAL1, could help blunt the growth of neuroblastoma, a cancer of nerve tissue, in cell cultures and mice.

Dang also has recently studied a class of anti-tumor drugs that failed in clinical testing 10 to 20 years ago. They all caused such low platelet counts that they never progressed past early trials.

Now, in mouse experiments, Dang’s team has found that timing is key. Drugs given at 10 a.m. or 6 p.m. both caused tumor regression, but only the 6 p.m. treatment caused low platelet counts. Perhaps, he says, patients in those early trials were given the drugs at the wrong time.

Another drug that doctors may be administering suboptimally is streptozocin, used to treat a rare form of pancreatic cancer. A 2017 mouse study showed that timing streptozocin administration minimized drug toxicity. And although research results in mice often don’t translate to people, the scientists behind this finding hope to test this schedule in patients.

Other data suggest that resetting clocks in tumors could mitigate cancer side effects such as low blood-cell counts and perhaps cachexia, a devastating loss of body weight and strength that often afflicts people in the final stages of cancer.

At the moment, only one chronotherapy clinical trial is running in the United States. It’s happening at the Washington University School of Medicine in St. Louis, where neuro-oncologist Jian Campian and colleagues over the past two years have treated 30 brain cancer patients with the chemotherapy drug temozolomide at 8 a.m. or 8 p.m.

So far, Campian said, it looks as if the drug’s side effects are far worse when people take it in the morning, though it’s too early to say anything conclusive.

A sticking point for timed treatment is that people differ. We all have “chronotypes” that determine whether we are morning or evening people, and that will probably affect responses to cancer drugs, notes Campian’s collaborator Erik Herzog. Ideally, treatment timings would be finely tuned to patients — “the ultimate personalized medicine,” Herzog says.

But precisely and noninvasively measuring people’s clocks, or the clock of their tumors, is no small task. “We still need to identify better biomarkers to personalize chronotherapy,” says Francis Lévi, a chronotherapy researcher at the University of Warwick in Britain.

For now, most human data comes from anecdotal reports such as those of Joe Kuna, who was diagnosed with metastatic colon cancer in 2014 and given two to five years to live. Four years on, the 61-year-old has survived a tennis-ball-size tumor in his colon and 15 lesions in his liver. Kuna, who runs a bowling alley in Johnsburg, Illinois, opted to undergo chronotherapy at the nearby Block Center for Integrative Cancer Treatment in Skokie.

For almost two years, Kuna would arrive at the center every other Tuesday, usually between 1 p.m. and 3:30 p.m., for his dose of oxaliplatin. Oncologist Keith Block, medical director of the clinic, said oxaliplatin seems to work best in the afternoon.

Kuna would sit in a cubicle and eat his tuna fish sandwich while the intravenous medication dripped into his veins through a port.

Another drug in Kuna’s chemotherapeutic cocktail, fluorouracil, is considered more of a nighttime agent — so Kuna took home a pump that was programmed to kick in at 10 p.m.

“I truly believe it’s why I’m still here,” Kuna said of this treatment and the diet and supplement regimen he followed. Although a scan in January revealed two new cancerous spots in his liver, Kuna is confident that, with surgery and more chronotherapy, he could be cancer-free once more. Doctors removed the new tumors on April 26.

Still, there’s no proof that Kuna’s treatment made a difference. The other patients he befriended at the Block Center are not alive today.

Most chronotherapy strategies are based on a limited understanding of clock biology — which frustrates Dang, who has yet to test any of his ideas surrounding drug timing in patients.

“We really want to provide the mechanistic basis of why you treat at a certain time of day, and not just rely on trial and error,” he said.

But perhaps, just as a small career move reshaped his own research, “it could be,” he said, “that simple adjustments make a big difference for patients.”

[“source=doctor.ndtv”]

Another Reason To Control Your Blood Pressure Levels: Keeps Dementia Away

Another Reason To Control Your Blood Pressure Levels: Keeps Dementia Away

For the first time in history, researchers have found medicine that can reduce the risk of memory loss and dementia in your golden years. Even better, most forms of the treatment are available in safe, inexpensive generic formulations.The twist? These drugs have been around for decades, since they’re widely used to lower blood pressure and ward off heart disease.

As the population ages, the incidence of cognitive impairment and dementia has surged. One in six women over the age of 55 and 10 percent of men are expected to develop dementia before they die. Alzheimer’s disease, the most common type, affects more than 5 million Americans and is the sixth leading cause of death in the country. And while the drug industry has spent billions of dollars trying to slow down memory loss once it begins, the efforts have been largely unsuccessful. Until now.

The Systolic Blood Pressure Intervention Trial, or Sprint, was begun in 2010 to see if aggressively lowering blood pressure would reduce a range of health complications, including heart disease and dementia. The heart disease portion was halted five years later because the benefits were overwhelming. Researchers continued to track the cognitive function of 9,361 participants in a separate analysis called Sprint Mind through June.

The results, presented at the Alzheimer’s Association International Conference in Chicago, found that those who initially received intensive blood pressure control were 19 percent less likely to develop mild cognitive impairment than those who had more relaxed hypertension goals. The risk of developing either cognitive impairment or dementia was 15 percent lower, while dementia rates alone weren’t significantly different in the study.

“What is good for your heart is not only good for your heart, but also good for your brain,'” said Jeff Williamson, the lead researcher and chief of gerontology and geriatric Medicine at Wake Forest School of Medicine.

The researchers weren’t particular about what drug regimen the patients used, as long as they got to their goals. Those in the intensive treatment arm were expected to get below 120 mmHg, the upper number in a blood pressure reading, while those in the standard treatment group aimed for 140 mmHg.

Williamson compared the findings to car tires: “You want to have the right pressure,” he said. “If it’s too high or too low, the tires can wear out quickly. With blood pressure, if it’s too high, the walls of the arteries can endure damage.”

The findings will allow people to take action in their own lives to lower their risk, with specific goals to aim for, said James Hendrix, director of global science initiatives at the Alzheimer’s Association. Many people aren’t at recommended blood pressure levels, he said, and evidence that better control helps the heart and the brain may push them into action.

“People may do all the right things and still develop dementia, but this may give them more time,” he said. “It may give another five or 10 years with a healthy brain.”

[“source=doctor.ndtv”]

PSG Optimistic Over Fitness Of Kylian Mbappe, Neymar For Liverpool Showdown

PSG Optimistic Over Fitness Of Kylian Mbappe, Neymar For Liverpool Showdown

It has been a month marred by off-field controversies for Paris Saint-Germain, but it is the fitness of Kylian Mbappe and Neymar that casts the longest shadow over the French club ahead of Wednesday’s Champions League crunch clash against Liverpool. PSG go into the game at the Parc des Princes in third place in Group C, and a defeat against last season’s runners-up, coupled with a win for Napoli at home to Red Star Belgrade, would condemn the Qatar-owned side to an early elimination.

Such a prospect is unthinkable for a club with the ambitions of PSG, who are desperate to improve on consecutive exits from the Champions League in the last 16.

[“source=ndtv”]